本期文章：《科学》：Online/在线发表
广泛表达单倍体偏倚基因实现精子水平的自然选择，这一成果由美国Ohana生物科学Robin C. Friedman研究小组经过不懈努力而取得。该研究于2021年1月14日发表于国际学术期刊《科学》杂志。
研究人员发现在许多哺乳动物中，基因在这些细胞质桥之间并不完全共享。研究人员将这些基因称为“基因信息标记”（GIM），并表明一个子集可以充当各自的遗传元素，这些等位基因在小鼠、牛和人群中分布不均等位基因。研究人员确定进化压力消除了精子和体细胞功能之间的冲突，因为GIMs丰富了睾丸特异性基因的表达、旁系同源物和同工型。因此，GIM和精子水平的自然选择可能有助于解释为什么睾丸基因表达模式相对于其他所有组织而言是离群值。
研究人员表示，精子虽然是单倍体，但其在功能上必须等效这样才能在子代之间平均分配等位基因。 因此，精子通过细胞质桥共享基因产物，其消除了单个单倍体精子之间的表型差异。
附：英文原文
Title: Widespread haploid-biased gene expression enables sperm-level natural selection
Author: Kunal Bhutani, Katherine Stansifer, Simina Ticau, Lazar Bojic, Alexandra-Chloé Villani, Joanna Slisz, Claudia M. Cremers, Christian Roy, Jerry Donovan, Brian Fiske, Robin C. Friedman
Issue&Volume: 2021/01/14
Abstract: Sperm are haploid, but must be functionally equivalent to distribute alleles equally among progeny. Accordingly, gene products are shared through spermatid cytoplasmic bridges which erase phenotypic differences between individual haploid sperm. Here, we show that a large class of mammalian genes are not completely shared across these bridges. We term these genes “genoinformative markers” (GIMs) and show that a subset can act as selfish genetic elements that spread alleles unevenly through murine, bovine, and human populations. We identify evolutionary pressure to avoid conflict between sperm and somatic function as GIMs are enriched for testis-specific gene expression, paralogs, and isoforms. Therefore, GIMs and sperm-level natural selection may help explain why testis gene expression patterns are an outlier relative to all other tissues.
DOI: 10.1126/science.abb1723
Source: https://science.sciencemag.org/content/early/2021/01/13/science.abb1723
期刊信息
Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037
官方网址：https://www.sciencemag.org/
