CHM发生在一位女性身上，她在体外将一个假定的圆形精子细胞注射到她的一个卵母细胞中，并将囊胚植入子宫内。CHM基因与她丈夫的外周血白细胞相同，不含母体来源的核DNA。
研究组假设，工作人员无意中选择了一个精原细胞，而非一个圆形精子细胞。CHM发展为妊娠滋养细胞瘤，化疗后消退。
附：英文原文
Title: Spermatogonium-Derived Complete Hydatidiform Mole
Author: Hirokazu Usui, M.D., Ph.D.,, and Makio Shozu, M.D., Ph.D.
Issue&Volume: 2021-03-10
Abstract: A complete hydatidiform mole (CHM) is a conceptus with only sperm-derived chromosomes. Here, we report on a CHM with genomic DNA identical to that of the paternal somatic cells. The CHM developed in a woman who had undergone intrauterine implantation of a blastocyst obtained through in vitro injection of a presumed round spermatid into one of her oocytes. The CHM was genetically identical to peripheral white cells of her husband and contained no maternally derived nuclear DNA. We hypothesize that a spermatogonium, rather than a round spermatid, was inadvertently selected for the procedure. The CHM developed into a gestational trophoblastic neoplasia, which resolved after chemotherapy.
DOI: 10.1056/NEJMoa2005756
Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2005756
期刊信息
The New England Journal of Medicine：《新英格兰医学杂志》，创刊于1812年。隶属于美国麻省医学协会，最新IF：70.67
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